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gene 2,041 words KG: ent-gene-f920125e
Contents

ABI3 Gene

🧬 Gene Info
Gene SymbolABI3
Full NameABI Family Member 3 (Abl Interactor 3)
AliasesAbl Interactor 3, ABI3 protein
Chromosome17q21.31
Functionis a gene located on chromosome 17q21.
Molecular Weight52 kDa
Amino Acids360 aa
UniProt IDQ9NZU7
NCBI Gene ID10027
Ensembl IDENSG00000108506
OMIM609469
GeneCardsABI3
Human Protein AtlasABI3
Associated DiseasesALZHEIMER'S DISEASE, DEMENTIA
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, COMPLEMENT, LRP1
KG Connections107 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Membrane Cholesterol Gradient Modulators
Score: 0.71Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62APOE-TREM2 Interaction Modulation
Score: 0.74TREM2-Dependent Microglial Senescence Transition
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withACE Gene
gene · KG edge: associated_withadam17
gene · KG edge: associated_withAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (1 edges)

ent-gene-f920125e has_risk_variant rs616338

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