| Gene Symbol | AIFM1 |
| Function | encodes a crucial flavoprotein that plays dual roles in both normal mitochondrial function and programmed cell death. |
| Molecular Weight | 63 kDa |
| Amino Acids | 613 aa |
| Pathways | Apoptosis, Mapk, Wnt signaling, apoptosis pathway, MAPK signaling |
| Ensembl ID | ENSG00000156509 |
| GeneCards | AIFM1 |
| Human Protein Atlas | AIFM1 |
| FAD-binding domain | Residues 150-400, binds FAD cofactor essential for NADH oxidase activity |
| DNA-binding domain | C-terminal region (residues 400-613) can bind DNA in the nucleus |
| Proline-rich region | Contains SH3-binding motifs for protein interactions |
| Complex I assembly | Critical for proper assembly and stability of NADH:ubiquinone oxidoreductase (Complex I) |
| NADH oxidation | Functions as a NADH oxidase using FAD as cofactor, contributing to mitochondrial redox balance |
| Mitochondrial DNA maintenance | Required for mitochondrial DNA (mtDNA) transcription and replication |
| Iron-sulfur cluster biogenesis | Involved in assembly of Fe-S clusters essential for multiple mitochondrial enzymes |
| Associated Diseases | ALS |
| Interactions | NLRP3, TREM2, LRP1, S100A9, MAPK1, NLRP1 |
| KG Connections | 98 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |