| Gene Symbol | ANXA1 |
| Full Name | Annexin A1 |
| Chromosome | 9q21.13 |
| Target Class | Signaling Protein |
| Function | ANXA1 performs diverse cellular functions: |
| Mechanism of Action | Calcium-dependent phospholipid binding protein modulator |
| Primary Expression | the nervous system: |
| Druggability | Low (0.41) |
| Clinical Stage | Approved |
| Molecular Weight | ~37 kDa |
| Amino Acids | 346 aa |
| Exons | 13 |
| Pathways | Apoptosis, Blood-Brain Barrier, Immune Response, Mtor, cGAS/STING Pathway |
| UniProt ID | P04083 |
| NCBI Gene ID | 303 |
| Ensembl ID | ENSG00000109255 |
| OMIM | 151690 |
| GeneCards | ANXA1 |
| Human Protein Atlas | ANXA1 |
| Associated Diseases | aging, ALS, Alzheimer, cancer |
| Known Drugs/Compounds | aducanumab, GW201, Tat-Nts, Tat-NTS, Tat-NTS peptide |
| Interactions | AKT, AMPK, AND, APOPTOSIS, AUTOPHAGY, BECN1 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Synaptic Phosphatidylserine Masking via Annexin A1 |
| KG Connections | 508 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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