| Gene Symbol | APE1 |
| Full Name | AP Endonuclease 1 |
| Protein Type | Enzyme |
| Function | APE1 (Apurinic/Apyrimidinic Endonuclease 1) is a essential DNA repair enzyme that plays a critical role in the base excision repair (BER) pathway. |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000100823 |
| GeneCards | APE1 |
| Human Protein Atlas | APE1 |
| p53 dysregulation | APE1's redox regulation of p53 is impaired, affecting apoptosis decisions |
| Mitochondrial vulnerability | dopaminergic neurons rely on APE1 for mtDNA repair |
| α-synuclein interaction | pathological alpha-synuclein can interfere with APE1's DNA binding and repair function |
| LRRK2 connection | LRRK2 kinase activity may modulate APE1 function; G2019S mutations affect DNA damage responses |
| Associated Diseases | Als |
| Interactions | PINK1, OXIDATIVE STRESS, PKM2, P62, KEAP1, SQSTM1 |
| KG Connections | 26 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |