gene 2,164 words KG: ATG10 2026-03-28
kind:genesection:genesstate:published
Contents

ATG10 Gene

🧬 Gene Info
Gene SymbolATG10
Full NameAutophagy Related 10
Chromosome5q21.3
Protein TypeEnzyme
Functionencodes an E2-like conjugating enzyme that plays an essential role in the autophagy conjugation system.
Primary Expressiontissues throughout the body, with particularly important functions in neurons where autophagy is crucial for synaptic maintenance, mitochondrial quali
Molecular Weight21 kDa
Amino Acids182 aa
PathwaysAutophagy, Chaperone, Epigenetic, Mtor, Sod1
UniProt ID[Q9Y4K0](https://www.uniprot.org/uniprot/Q9Y4K0)
Ensembl IDENSG00000138107
OMIM610070
GeneCardsATG10
Human Protein AtlasATG10
Associated Diseasesneurodegeneration
InteractionsLAMP1, STIP1, TREH, CTSB, MCOLN1, GLA
KG Connections153 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
Cryptic Exon Silencing Restoration
Score: 0.46

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
BECN1 Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates
BAG3 Gene
gene · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: activates

Knowledge Graph (12 edges)

ATG10 activates LAMP1
ATG10 activates STIP1
ATG10 activates TREH
ATG10 activates CTSB
ATG10 activates MCOLN1
ATG10 regulates ATF4
ATG10 expressed_in WIPI2
ATG10 activates GLA
ATG10 activates HSPA8
ATG10 activates TARDBP