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gene 1,231 words KG: ent-gene-771d7f4d
Contents

ATF4 Gene

🧬 Gene Info
Gene SymbolATF4
Full NameActivating Transcription Factor 4
Chromosome22q13.1
Protein TypeTranscription Factor
FunctionAmino acid metabolism: Upregulates genes involved in amino acid transport and synthesis
Molecular Weight38.6 kDa
PathwaysApoptosis, Autophagy, Epigenetic, Er Stress, Ferroptosis
UniProt ID[P18848](https://www.uniprot.org/uniprot/P18848)
GeneCardsATF4
Human Protein AtlasATF4
Associated DiseasesAging, Atherosclerosis, cancer, Glioblastoma, Tumor
Known Drugs/Compoundsrapamycin
InteractionsACSL4, Actin, AGING, AKT, AMPK, AMYLOID
SciDEX HypothesesATF4-DDIT3 stress signaling indirectly represses M
KG Connections565 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79CYP46A1 Overexpression Gene Therapy
Score: 0.77Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Senescence-Activated NAD+ Depletion Rescue
Score: 0.76SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Extracellular Matrix Stiffness Modulation
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68RNA Granule Nucleation Site Modulation
Score: 0.66Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Vagal Afferent Microbial Signal Modulation
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62VCP-Mediated Autophagy Enhancement
Score: 0.59
pg 1/2Next →

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Astrocytes
cell · KG edge: expressed_inATP P2X3 Receptor Neurons
cell · KG edge: expressed_inAMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (4 edges)

h-2901c57778 targets ent-gene-771d7f4d
ent-gene-771d7f4d targeted_by h-2901c57778
ent-gene-771d7f4d data_in benchmark_ot_ad_answer_key:ATF4
benchmark_ot_ad_answer_key:ATF4 data_in ent-gene-771d7f4d

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