gene 679 words KG: BAG3 2026-03-24
kind:genesection:genesstate:published
Contents

BAG3 Gene

🧬 Gene Info
Gene SymbolBAG3
Full NameBCL2 Associated Athanogene 3
AliasesBAG3, BIS, MFM
Chromosome10
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight57.5 kDa
Amino Acids575 aa
Exons4
PathwaysAutophagy, Complement, Nf-Κb
GeneCardsBAG3
Human Protein AtlasBAG3
Location10q25.2
Associated DiseasesALS, ALZHEIMERS_DISEASE, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Astrocyte Phagocytosis
Known Drugs/Compoundsrapamycin
InteractionsATG10, CLOCK, ATG12, HSPB8, BMAL1, STUB1
KG Connections413 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
ATG12 — Autophagy Related 12
gene · KG edge: activates
ATG10 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BAG3 regulates BECN1
BAG3 regulates CTSB
BAG3 regulates GLA
BAG3 regulates HSPB8
BAG3 regulates LAMP2A
BAG3 regulates MAP1LC3B
BAG3 regulates MCOLN1
BAG3 regulates P62
BAG3 regulates PPARGC1A
BAG3 regulates TFEB