gene 1,028 words KG: ATP5A1 2026-03-24
kind:genesection:genesstate:published
Contents

ATP5A1 Gene

🧬 Gene Info
Gene SymbolATP5A1
Full NameATP Synthase Subunit Alpha
Chromosome21q21.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids553 aa
UniProt ID[P25788](https://www.uniprot.org/uniprot/P25788)
Ensembl IDENSG00000188039
GeneCardsATP5A1
Human Protein AtlasATP5A1
Protein Size553 amino acids, ~60 kDa
TopologyMatrix-facing F1 domain
Oligomeric StateForms part of the alpha3beta3 hexamer with 3 alpha (ATP5A1) and 3 beta (ATP5B) subunits
Post-translational ModificationsKnown to be phosphorylated and acetylated, affecting enzyme activity and assembly
Associated Diseasesneurodegeneration
InteractionsSOD1, EGFR, GRIA1, MAPK1, ACTG1, YWHAZ
KG Connections81 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

huntington-disease-treatment
therapeutic · KG edge: therapeutic_target
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: therapeutic_target
YWHAZ Gene
gene · KG edge: interacts_with
SNCA — Alpha-Synuclein
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ATP5A1 interacts_with SOD1
ATP5A1 interacts_with EGFR
ATP5A1 interacts_with GRIA1
ATP5A1 interacts_with MAPK1
ATP5A1 interacts_with ACTG1
ATP5A1 interacts_with YWHAZ
ATP5A1 downregulates energy metabolism
ATP5A1 activates CALCOCO2
ATP5A1 activates HSP60
ATP5A1 activates HSPD1