gene 639 words KG: GRIA1 2026-03-24
kind:genesection:genesstate:published
Contents

GRIA1 Gene

🧬 Gene Info
Gene SymbolGRIA1
Full NameGlutamate Ionotropic Receptor AMPA Type Subunit 1
Chromosome5q31.1
FunctionThe GRIA1 gene encodes the GluA1 protein subunit, one of four subunits (GluA1-4) that assemble to form AMPA-type ionotropic glutamate receptors.
PathwaysEpigenetic, Synaptic Plasticity
UniProt IDP42262
NCBI Gene ID2891
Ensembl IDENSG00000155545
OMIM138248
GeneCardsGRIA1
Human Protein AtlasGRIA1
Associated DiseasesAging, Als, Alzheimer, Autism, Bipolar, Cancer
InteractionsADRA1A, HRH1, GRIN1, HCRTR1, SNAP25, ACTG1
KG Connections193 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Orexin-Microglia Modulation Therapy
Score: 0.49
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
CDC42 Gene
gene · KG edge: interacts_with
cct2
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

GRIA1 activates ADRA1A
GRIA1 activates HRH1
GRIA1 activates GRIN1
GRIA1 activates HCRTR1
GRIA1 interacts_with SNAP25
GRIA1 interacts_with ACTG1
GRIA1 interacts_with SNCA
GRIA1 interacts_with GAPDH
GRIA1 interacts_with MAPK1
GRIA1 interacts_with PSMA3