gene 876 words KG: PSMA3 2026-03-24
kind:genesection:genesstate:published
Contents

PSMA3 Gene

🧬 Gene Info
Gene SymbolPSMA3
Full NameProteasome 20S Subunit Alpha 3
Chromosome14q23.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight28.1 kDa
Amino Acids255 aa
PathwaysAutophagy, Proteasome
NCBI Gene ID5684
Ensembl IDENSG00000172863
GeneCardsPSMA3
Human Protein AtlasPSMA3
Protein ProductPSMA3 Protein
Complex Membership20S/26S ubiquitin-proteasome system
Disease RelevanceProteostasis vulnerability in Alzheimer's Disease, Parkinson's Disease, ALS
Associated DiseasesALS, Alzheimer, dementia, neurodegeneration
InteractionsSOX2, YWHAZ, HSP90AB1, ACTB, CDC42, ATP5A1
KG Connections71 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

huntington-disease-treatment
therapeutic · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: therapeutic_target
MAPK1 Gene
gene · KG edge: interacts_with
HSP90AB1 Gene
gene · KG edge: interacts_with
GRIA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PSMA3 interacts_with SOX2
PSMA3 interacts_with YWHAZ
PSMA3 interacts_with HSP90AB1
PSMA3 interacts_with ACTB
PSMA3 interacts_with CDC42
PSMA3 interacts_with ATP5A1
PSMA3 interacts_with SOD1
PSMA3 interacts_with EGFR
PSMA3 regulates PSMC1
PSMA3 regulates AMBRA1