gene 866 words KG: MAPK1 2026-03-24
kind:genesection:genesstate:published
Contents

MAPK1 Gene

🧬 Gene Info
Gene SymbolMAPK1
Full NameMitogen-Activated Protein Kinase 1
Chromosome22q11.22
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight41 kDa
Amino Acids360 aa
PathwaysMAPK, Mapk, MAPK signaling, MAPK pathway
UniProt IDP28482
NCBI Gene ID5594
Ensembl IDENSG00000100030
OMIM176948
GeneCardsMAPK1
Human Protein AtlasMAPK1
Associated DiseasesALS, Aging, Alzheimer, Cancer, Carcinoma
Known Drugs/CompoundsZuojin Pill, Chrysotoxine, DEP, DMP, DOP
InteractionsMAP1LC3B, MTOR, TLR4, LC3, TFEB, AKT
KG Connections948 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Retinal Vascular Microcirculation Rescue
Score: 0.54

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

Alzheimer Indonesia
institution · KG edge: activates
AKT1 Gene
gene · KG edge: activates
AIFM1 Gene
gene · KG edge: activates
ACVR1 Gene
gene · KG edge: interacts_with
ACTG1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

MAPK1 inhibits MAP1LC3B
MAPK1 inhibits MTOR
MAPK1 inhibits TLR4
MAPK1 inhibits LC3
MAPK1 activates TFEB
MAPK1 activates AKT
MAPK1 therapeutic_target CTSD
MAPK1 therapeutic_target HIF1A
MAPK1 inhibits PI3K
MAPK1 interacts_with APP