gene

ACTG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

38Outgoing

30Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ACTG1
Full Name	Actin Gamma 1 (Cytoplasmic)
Chromosome	17q25.3
Primary Expression	neuronal cells and inner ear hair cells
Amino Acids	20 aa
Exons	6
UniProt ID	P63261
NCBI Gene ID	72
Ensembl ID	ENSG00000184009
OMIM	102560
GeneCards	ACTG1
Human Protein Atlas	ACTG1
Gene Length	4.8 kb
mRNA Length	1.2 kb
Feature	Gamma-Actin
Associated Diseases	Ms
Interactions	SNCA, GAPDH, MAPK1, PSMA3, SOX2, YWHAZ
KG Connections	68 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ACTG1 — AlphaFold P63261 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ACTG1["ACTG1"] -->|"therapeutic target"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACTG1["ACTG1"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACTG1["ACTG1"] -->|"therapeutic target"| Huntington["Huntington"]
    style Huntington fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACTG1["ACTG1"] -->|"therapeutic target"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACTG1["ACTG1"] -->|"interacts"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACTG1["ACTG1"] -->|"interacts"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ACTG1["ACTG1"] -->|"therapeutic target"| Prion["Prion"]
    style Prion fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    CCT2["CCT2"] -->|"interacts"| ACTG1["ACTG1"]
    style CCT2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"therapeutic target"| ACTG1["ACTG1"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GFAP["GFAP"] -->|"interacts"| ACTG1["ACTG1"]
    style GFAP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GRIA1["GRIA1"] -->|"interacts"| ACTG1["ACTG1"]
    style GRIA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SNAP25["SNAP25"] -->|"interacts"| ACTG1["ACTG1"]
    style SNAP25 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ACTG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (38)

Target	Relation	Type	Str
Neuronal Apoptosis	promotes	process	0.90
TP53	binds	protein	0.85
neuronal apoptosis	promotes	process	0.85
TP53	associated_with	protein	0.80
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Prion	therapeutic_target	disease	0.65
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
SOX2	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
OTUD6A	targets	gene	0.60
OTUD6A	activates	gene	0.60
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Mapk	interacts_with	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
PSMD14	interacts_with	gene	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (30)

Source	Relation	Type	Str
Otud6A	associated_with	protein	0.95
OTUD6A	interacts_with	gene	0.95
OTUD6A	degrades	enzyme	0.95
Otud6A	interacts_with	protein	0.90
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTB	associated_with	gene	0.60
SOX2	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
VESICLE TRAFFICKING	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PSMD14	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ACTG1

Understanding Entity Pages

Wiki Pages (9)

ACTG1 Gene

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Actin Cytoskeleton Dynamics in Neurodegeneration

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ACTB Gene

ATP5A1 Gene

Genes Overview