gene 2,375 words KG: C19ORF12
Contents

C19orf12 Gene - Chromosome 19 Open Reading Frame 12

🧬 Gene Info
Gene SymbolC19ORF12
Chromosome19q12
Functionencodes a mitochondrial membrane protein that is highly expressed in the brain.
Subcellular LocalizationC19orf12 localizes to:
Molecular Weight17 kDa
Amino Acids152 aa
Exons4
Ensembl IDENSG00000131368
GeneCardsC19ORF12
Human Protein AtlasC19ORF12
Transmembrane domainsTwo predicted transmembrane helices
Coiled-coil regionsMediate protein-protein interactions
Lipid-binding domainsInteract with membrane lipids
Mitochondrial outer membranePrimary location
Endoplasmic reticulumSecondary localization in some cell types
Associated DiseasesDystonia, Iron Accumulation, Ms, Neurodegeneration, Parkinson
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.89
Blood-Brain Barrier SPM Shuttle System
Score: 0.75
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Sphingolipid Metabolism Reprogramming
Score: 0.66

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
COASY Gene
gene · KG edge: associated_with
DCAF17 Gene - DDB1 and CUL4 Associated Factor 17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FTL associated_with C19ORF12
WDR45 associated_with C19ORF12
COASY associated_with C19ORF12
DCAF17 associated_with C19ORF12
FA2H associated_with C19ORF12
C19ORF12 associated_with PANK2
C19ORF12 associated_with PLA2G6
C19ORF12 associated_with Iron Accumulation
C19ORF12 regulates Lysosomal Acidification
C19ORF12 associated_with Neurodegeneration

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