gene 980 words KG: WDR45 2026-03-22
kind:genesection:genesstate:published
Contents

WDR45 - WD Repeat Domain 45

🧬 Gene Info
Gene SymbolWDR45
Full NameWD Repeat Domain 45
AliasesPage for WDR45, WIPR1
ChromosomeXp11.23<br/>
FunctionWDR45 (also called WIPR1) participates in autophagy
Primary Expressionneuronal tissues:
Molecular Weight39 kDa
PathwaysmTOR, mtor
UniProt IDQ9Y5X9
NCBI Gene ID11152
Ensembl IDENSG00000196998
GeneCardsWDR45
Human Protein AtlasWDR45
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, BPAN, Cancer, Cardiovascular
Known Drugs/Compoundsrapamycin
InteractionsG3BP1, ATG2A, PIK3C3, ESR2, HDAC6, SOX9
KG Connections256 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

APOE-Dependent Autophagy Restoration
Score: 0.61
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.52

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Wilson Disease Neurodegeneration: Mechanism and Therapeutic
clinical · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
ATG2A
gene · KG edge: activates
ar
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

WDR45 associated_with BECN1
WDR45 associated_with HDAC6
WDR45 associated_with ESR1
WDR45 associated_with PSEN1
WDR45 associated_with MAP1LC3B
WDR45 associated_with UVRAG
WDR45 associated_with APP
WDR45 associated_with MTOR
WDR45 associated_with PIK3C3
WDR45 associated_with VDAC2