gene 1,155 words KG: COASY 2026-03-28
kind:genesection:genesstate:publishedtopic:parkinsonstopic:alzheimerstopic:nbia
Contents

COASY Gene

🧬 Gene Info
Gene SymbolCOASY
Full NameCoenzyme A Synthetase
Chromosome17q21.2
Protein TypeEnzyme
Functionencodes a bifunctional enzyme that plays a critical role in the coenzyme A (CoA) biosynthetic pathway.
Molecular Weight80 kDa
Amino Acids724 aa
Exons15
UniProt IDQ9P2R3
NCBI Gene ID80317
Ensembl IDENSG00000167468
OMIM609856
GeneCardsCOASY
Human Protein AtlasCOASY
ATP-binding motifRequired for both kinase and adenylyltransferase activities
Associated DiseasesDystonia, Ms, Neurodegeneration, Parkinson
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
APOE Isoform Expression Across Glial Subtypes
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Oligodendrocyte White Matter Vulnerability
Score: 0.40

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: associated_with
WDR45 - WD Repeat Domain 45
gene · KG edge: associated_with
PLA2G6 — Phospholipase A2 Group VI
gene · KG edge: associated_with
PANK2 — Pantothenate Kinase 2
gene · KG edge: associated_with
FTL Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

COASY associated_with DCAF17
COASY associated_with FA2H
COASY associated_with C19ORF12
COASY associated_with PANK2
COASY associated_with PLA2G6
COASY associated_with Neurodegeneration
COASY associated_with Ms
COASY associated_with Parkinson
COASY associated_with Dystonia
COASY associated_with Lipid Metabolism