gene 3,327 words KG: FA2H
Contents

FA2H Gene

🧬 Gene Info
Gene SymbolFA2H
Chromosome16q23.1
FunctionFa2H Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localizationto the endoplasmic reticulum (ER) membrane in myelinating cells including oligod
Amino Acids383 aa
Exons13
PathwaysLipid Metabolism, Mitophagy, Autophagy
GeneCardsFA2H
Human Protein AtlasFA2H
Lipid TypeStructure
2-OH galactosylceramideGalactose-2-OH FA-ceramide
2-OH glucosylceramideGlucose-2-OH FA-ceramide
2-OH sulfatideSulfate-2-OH FA-ceramide
2-OH ceramideBase-2-OH FA
Variant TypeEffect
Associated DiseasesALS, Dystonia, Ms, Neurodegeneration, Parkinson
InteractionsFTL, PANK2, PLA2G6, WDR45, ATP13A2, CP
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Peroxisomal Dysfunction Validation in Parkinson's Disease
validation · proposed · Score: 0.40

See Also (11)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: associated_with
WDR45 - WD Repeat Domain 45
gene · KG edge: associated_with
PLA2G6 — Phospholipase A2 Group VI
gene · KG edge: associated_with
PANK2 — Pantothenate Kinase 2
gene · KG edge: associated_with
FTL Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FA2H associated_with C19ORF12
FA2H associated_with PANK2
FA2H associated_with PLA2G6
FA2H co_expressed_with PANK2
FA2H co_expressed_with PLA2G6
FA2H associated_with neurodegeneration
FA2H interacts_with neurodegeneration
FA2H interacts_with FTL
FA2H interacts_with PANK2
FA2H interacts_with PLA2G6