Contents

CACNA1D Gene

🧬 Gene Info

Gene Symbol	CACNA1D
Chromosome	3p21.1
Protein Family	Voltage-gated calcium channel (Cav1) family
Function	CACNA1D encodes the α1D subunit of voltage-dependent L-type calcium channels, also known as Cav1.3
Primary Expression	neurons, cardiac pacemaker cells, and endocrine cells
Subcellular Localization	Cell membrane, dendritic shafts, presynaptic terminals
Molecular Weight	245 kDa
UniProt ID	[Q01658](https://www.uniprot.org/uniprot/Q01658)
GeneCards	CACNA1D
Human Protein Atlas	CACNA1D
α1 Subunit (CACNA1D)	Forms the transmembrane pore
β Subunit	Auxiliary subunit affecting trafficking and kinetics
α2δ Subunit	Auxiliary subunit increasing surface expression
γ Subunit	Modulatory subunit (in some tissues)
Low-Voltage Activation	Activates at potentials as negative as -50 mV (vs. -30 mV for Cav1.2)
Associated Diseases	neurodegeneration
Interactions	CACNA1A, CACNA1C, CACNA1E, cacna1f, CACNA1F, CACNA1G
KG Connections	36 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph