| Gene Symbol | CACNA1E |
| Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 E |
| Aliases | Cav2.3 R-type Calcium Channel |
| Chromosome | 1q25.1 |
| Function | The CACNA1E gene encodes the α1E subunit that forms the pore of the R-type voltage-gated calcium channel (CaV2.3). |
| Primary Expression | hippocampal neurons, cerebellar granule cells, and various cortical regions
- Dendritic localization: Primarily located on de |
| Molecular Weight | 250 kDa |
| Amino Acids | 233 aa |
| UniProt ID | Q15878 |
| NCBI Gene ID | 777 |
| Ensembl ID | ENSG00000198004 |
| GeneCards | CACNA1E |
| Human Protein Atlas | CACNA1E |
| Disease | Association Type |
| [Alzheimer's Disease](/diseases/alzheimers-disease) | Risk Modulator |
| Associated Diseases | Als |
| Interactions | CACNA1F, CACNA1I, CACNA2D1, CACNA2D2, CACNA1H, CACNA1G |
| KG Connections | 74 knowledge graph edges |
| Databases | GeneCardsHPASTRING |