gene 1,037 words KG: CACNA2D1 2026-04-01
kind:genesection:genesstate:published
Contents

CACNA2D1 Gene - Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1

🧬 Gene Info
Gene SymbolCACNA2D1
Full NameCalcium Channel Voltage-Dependent Subunit Alpha2 Delta 1
AliasesCaB1, CACNA2, α2δ1
Chromosome7q21.11
Protein TypeChannel
Functionis a critical component of L-type and N-type calcium channels, modulating channel trafficking, gating, and synaptic localization.
Primary ExpressionHigh in brain, skeletal muscle, heart
Amino Acids1256 aa
UniProt IDQ13926
NCBI Gene ID781
Ensembl IDENSG00000153991
OMIM114204
GeneCardsCACNA2D1
Human Protein AtlasCACNA2D1
Protein ClassCalcium channel auxiliary subunit
Associated Diseasesneurodegeneration
InteractionsCACNA1E, CACNA1H, CACNA1G, CACNA1A, CACNA1C, CACNA2D2
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (12)

GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: contributes_to
CCS Gene
gene · KG edge: contributes_to
CACNA2D2 Gene
gene · KG edge: associated_with
CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Al
gene · KG edge: associated_with
CACNA1H Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CACNA2D1 associated_with CACNA1E
CACNA2D1 associated_with CACNA1H
CACNA2D1 associated_with CACNA1D
CACNA2D1 associated_with CACNA1G
CACNA2D1 contributes_to GAIN
CACNA2D1 associated_with CACNA1F
CACNA2D1 associated_with CACNA1A
CACNA2D1 contributes_to CCS
CACNA2D1 associated_with CACNA2D2
CACNA2D1 associated_with CACNA1C