gene

CACNA1C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

225Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CACNA1C is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, expressed in. Associated with Als, Alzheimer, Anxiety. Connected to 77 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CACNA1C
Aliases	Page for Cav1.2
Function	CACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), one of the most important calcium channels in neurons and cardiac myocytes
Primary Expression	the brain, heart, and smooth muscle
Subcellular Localization	Somatodendritic compartment, dendritic spines, cardiac cells
Molecular Weight	250 kDa
Pathways	Wnt signaling, oxidative stress response
UniProt ID	Q13936
GeneCards	CACNA1C
Human Protein Atlas	CACNA1C
Drug	Use
Amlodipine	Hypertension, angina
Nifedipine	Hypertension
Verapamil	Arrhythmia, migraine
Nimodipine	Subarachnoid hemorrhage
Associated Diseases	Alzheimer, Anxiety, Cancer, Inflammation, Ms, psychiatric disorders
Interactions	CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I
KG Connections	225 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CACNA1C — AlphaFold Q13936 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CACNA1C["CACNA1C"] -->|"associated"| Cancer["Cancer"]
    CACNA1C["CACNA1C"] -->|"associated"| Alzheimer["Alzheimer"]
    CACNA1C["CACNA1C"] -->|"associated"| Ms["Ms"]
    CACNA1C["CACNA1C"] -->|"associated"| Inflammation["Inflammation"]
    CACNA1C["CACNA1C"] -.->|"inhibits"| Als["Als"]
    CACNA1C["CACNA1C"] -->|"associated"| Anxiety["Anxiety"]
    PIEZO1["PIEZO1"] -->|"expressed in"| CACNA1C["CACNA1C"]
    KCNK2["KCNK2"] -->|"associated"| CACNA1C["CACNA1C"]
    SCN5A["SCN5A"] -->|"associated"| CACNA1C["CACNA1C"]
    TRPM7["TRPM7"] -->|"associated"| CACNA1C["CACNA1C"]
    style CACNA1C fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (133)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	inhibits	disease	0.65
Anxiety	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
OVERVIEW	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
TRPV4	expressed_in	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNMA1	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
Axon Guidance	associated_with	pathway	0.60
TRPM7	causes	gene	0.60
SCN1A	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPA1	causes	gene	0.60
SCNN1A	causes	gene	0.60
PIEZO2	causes	gene	0.60
TRPV1	causes	gene	0.60
SCN5A	causes	gene	0.60
PIEZO1	associated_with	entity	0.60
TRPV4	associated_with	entity	0.60
KCNQ1	causes	gene	0.60
psychiatric disorders	associated_with	disease	0.60
CFTR	causes	gene	0.60
KCNMA1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
MMP2	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
IGF1R	therapeutic_target	gene	0.60

Incoming (92)

Source	Relation	Type	Str
CACNB3	participates_in	gene	0.70
PIEZO1	expressed_in	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	expressed_in	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
GAIN	activates	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
TRPM7	causes	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CDK5	therapeutic_target	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
APP	associated_with	gene	0.60
MAPT	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CACNA1C

Understanding Entity Pages

Summary

Wiki Pages (21)

CACNA1C Gene

Ion Channel Dysfunction in Huntington's Disease

Ion Channel Dysfunction in Alzheimer's Disease

ion-channel-dysfunction-disease-comparison

Calcium Dysregulation to Excitotoxicity Pathway

Calcium Dysregulation in Neurodegenerative Diseases

Calcium Homeostasis in Neurodegeneration

RNA Splicing Defects in Neurodegeneration

Calcium Homeostasis Dysfunction in CBS/PSP

CALB1 (Calbindin 1)

Calcium Dysregulation in 4R-Tauopathies — Cross-Disease Comparison

Gene Page: ANK2 (Ankyrin-2)

nfat-pathway-modulators-neurodegeneration

L-type Calcium Channel

KCNS3 (Kv9.3)

voltage-gated-calcium-channel-neurons

Calcium Dysregulation in Corticobasal Syndrome

RBM25 (RNA Binding Motif 25)

NEUROD2 Gene