gene 745 words KG: CACNA1A 2026-03-20
kind:genesection:genesstate:published
Contents

CACNA1A — Calcium Channel Alpha-1A Subunit

🧬 Gene Info
Gene SymbolCACNA1A
Full NameCalcium Voltage-Gated Channel Subunit Alpha1 A
AliasesCalcium Channel Alpha-1A Subunit
Chromosome19p13.13
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncerebellar Purkinje cells and hippocampal neurons, where it mediates:
UniProt IDO00555
NCBI Gene ID773
Ensembl IDENSG00000141837
OMIM601011
GeneCardsCACNA1A
Human Protein AtlasCACNA1A
Brain RegionExpression Level
CerebellumVery High (Purkinje cells)
[Hippocampus](/brain-regions/hippocampus)High (CA3, dentate gyrus)
Associated DiseasesAls, Ms
Known Drugs/CompoundsGW201
InteractionsCACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H
KG Connections68 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.38

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed

See Also (11)

Packard Center for ALS Research
institution · KG edge: associated_with
CACNA2D1 Gene - Calcium Channel Voltage-Dependent Subun
gene · KG edge: associated_with
CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Al
gene · KG edge: associated_with
CACNA1H Gene
gene · KG edge: associated_with
CACNA1G Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CACNA1A associated_with CHAT
CACNA1A associated_with FERMT2
CACNA1A associated_with OPTN
CACNA1A associated_with ABCA1
CACNA1A associated_with DPM2
CACNA1A associated_with TBK1
CACNA1A contributes_to CCS
CACNA1A associated_with CACNA1C
CACNA1A associated_with CACNA2D2
CACNA1A associated_with CACNA1F