gene

IDS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

4Analyses

37Outgoing

23Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	IDS
Full Name	Iduronate Sulfatase
Chromosome	Xq28
Protein Type	Enzyme
Function	Iduronate sulfatase is a member of the sulfatase family of enzymes that share a common mechanism of post-translational modification.
Primary Expression	most tissues:
Amino Acids	550 aa
Exons	9
UniProt ID	P22304
NCBI Gene ID	3423
Ensembl ID	ENSG00000010373
OMIM	309900
GeneCards	IDS
Human Protein Atlas	IDS
Protein Class	Lysosomal sulfatase
Associated Diseases	ALS, Alzheimer
Interactions	IGF2R, PRDX3, RNF14, SFPQ, SMARCB1, SORL1
KG Connections	60 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IDS — AlphaFold P22304 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IDS["IDS"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    SYNCRIP["SYNCRIP"]
    SSBP1["SSBP1"]
    PRDX3["PRDX3"]
    APP["APP"]
    ALZHEIMER["ALZHEIMER"]
    APOE["APOE"]
    SYNE2["SYNE2"]
    SMARCB1["SMARCB1"]
    ULK2["ULK2"]
    TMEM59["TMEM59"]
    SFPQ["SFPQ"]
    CCT4["CCT4"]
    CALB1["CALB1"]
    SORL1["SORL1"]
    IGF2R["IGF2R"]
    COPA["COPA"]
    STXBP3["STXBP3"]
    RNF14["RNF14"]
    IDS -.-|"associated"| Alzheimer
    IDS -.-|"associated"| Als
    IDS -.-|"associated"| SYNCRIP
    IDS -.-|"associated"| SSBP1
    IDS -.-|"associated"| PRDX3
    IDS -.-|"associated"| APP
    IDS -.-|"associated"| ALZHEIMER
    IDS -.-|"associated"| APOE
    IDS -.-|"associated"| SYNE2
    IDS -.-|"associated"| SMARCB1
    IDS -.-|"associated"| ULK2
    IDS -.-|"associated"| TMEM59
    IDS -.-|"associated"| SFPQ
    IDS -.-|"associated"| CCT4
    IDS -.-|"associated"| CALB1
    IDS -.-|"associated"| SORL1
    IDS -.-|"associated"| IGF2R
    IDS -.-|"associated"| COPA
    IDS -.-|"associated"| STXBP3
    IDS -.-|"associated"| RNF14
    style IDS fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (37)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
IGF2R	interacts_with	gene	0.60
PRDX3	interacts_with	gene	0.60
RNF14	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SMARCB1	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60
SYNCRIP	interacts_with	gene	0.60
SYNE2	interacts_with	gene	0.60
TMEM59	interacts_with	gene	0.60
ULK2	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Igf	associated_with	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60

Incoming (23)

Source	Relation	Type	Str
TMEM59	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
CALB1	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
COPA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

neurodegeneration | 2026-04-12 | 0 hypotheses

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IDS

Understanding Entity Pages

Wiki Pages (21)

IDS — Iduronate Sulfatase

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Parthanatos in Neurodegeneration

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

GRIA3 Gene

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

TREM2 Mechanism Hub

HNRNPA2B1 Protein

CNTN5 — Contactin 5

Mitochondrial Dysfunction in Parkinson's Disease

CLCN10 — Chloride Voltage-Gated Channel 10