protein

COPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

Summary

Page for COPA Protein

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🔬 Protein Info

Gene Symbol	COPA
Function	The WD40 domain forms a platform for multiple protein-protein interactions, enabling COPA to serve as a scaffold for the COPI coat assembly [@obrien2018].
Molecular Weight	140 kDa
Pathways	neuroinflammation
GeneCards	COPA
Human Protein Atlas	COPA
Associated Diseases	ALS, Alzheimer, Autoinflammatory Syndrome
Interactions	CGAS, NF-ΚB, AND, IFN, STING, Interferon
KG Connections	101 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    COPA(["COPA"])
    COPI["COPI"]
    Autoinflammatory_Syndrome["Autoinflammatory Syndrome"]
    Inflammation["Inflammation"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    neuroinflammation["neuroinflammation"]
    CGAS["CGAS"]
    NF__B["NF-KappaB"]
    AND["AND"]
    IFN["IFN"]
    STING["STING"]
    Er_Stress["Er Stress"]
    Nf__b["Nf-Kappab"]
    Fibroblast["Fibroblast"]
    STXBP3["STXBP3"]
    RNF14["RNF14"]
    IDS["IDS"]
    SYNCRIP["SYNCRIP"]
    SSBP1["SSBP1"]
    PRDX3["PRDX3"]
    COPA -->|"component_of"| COPI
    COPA -->|"causes"| Autoinflammatory_Syndrome
    COPA -->|"activates"| Inflammation
    COPA -.-|"associated"| Alzheimer
    COPA -.-|"associated"| Als
    COPA -->|"involved in"| neuroinflammation
    COPA -->|"activates"| CGAS
    COPA -->|"activates"| NF__B
    COPA -->|"activates"| AND
    COPA -->|"activates"| IFN
    COPA -->|"activates"| STING
    COPA -->|"activates"| Er_Stress
    COPA -->|"activates"| Nf__b
    COPA -->|"causes"| Fibroblast
    COPA -.-|"associated"| STXBP3
    COPA -.-|"associated"| RNF14
    IDS -.-|"associated"| COPA
    SYNCRIP -.-|"associated"| COPA
    SSBP1 -.-|"associated"| COPA
    PRDX3 -.-|"associated"| COPA
    style COPA fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (64)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
COPI	component_of	protein	0.90
Autoinflammatory Syndrome	causes	disease	0.90
Inflammation	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
neuroinflammation	involved_in	process	0.60
CGAS	activates	gene	0.60
NF-ΚB	activates	gene	0.60
AND	activates	gene	0.60
IFN	activates	gene	0.60
STING	activates	gene	0.60
Er Stress	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Fibroblast	causes	cell_type	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
AND	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
Interferon	interacts_with	protein	0.60
ULK2	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
Raf	transports	protein	0.60
Rb	activates	protein	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
Igf	associated_with	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
PRDX3	interacts_with	gene	0.60
RNF14	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SMARCB1	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60

Incoming (37)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
IFN	activates	gene	0.60
APP	interacts_with	gene	0.60
CGAS	activates	protein	0.50
STING	activates	gene	0.50
APOE	interacts_with	gene	0.50
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50
CALB1	interacts_with	gene	0.50
RNF14	interacts_with	gene	0.50
CCT4	interacts_with	gene	0.50
ULK2	interacts_with	gene	0.50
STXBP3	interacts_with	gene	0.50
SORL1	interacts_with	gene	0.50
SFPQ	interacts_with	protein	0.50
IGF2R	interacts_with	protein	0.50
benchmark_ot_ad_answer_key:COPA	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

COPA

Understanding Entity Pages

Summary

Wiki Pages (5)

IDS — Iduronate Sulfatase

cct4

COPA Protein