concept

SGMS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGMS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

0Hypotheses

1Analyses

50Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SGMS2
Key Genes/Proteins	SGMS1
Related Diseases	Alzheimer, Als, Ischemia, Stroke, ALS
Related Pathways	sphingomyelin

Wiki Pages (19)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SGMS2["SGMS2"]
    SGMS2 -->|"involved_in"| Sphingomyelin_Biosynthesis["Sphingomyelin Biosynthesis"]
    SGMS2 -->|"activates"| Alzheimer["Alzheimer"]
    SGMS2 -->|"inhibits"| Als["Als"]
    SGMS2 -->|"expressed in"| Ischemia["Ischemia"]
    SGMS2 -->|"expressed in"| Stroke["Stroke"]
    SGMS2 -->|"inhibits"| ALS["ALS"]
    AMYLOID__["AMYLOID Beta"] -->|"downregulates"| SGMS2
    h_fdb07848["h-fdb07848"] -->|"targets"| SGMS2
    FTY720["FTY720"] -->|"upregulates"| SGMS2
    SGMS1["SGMS1"] -->|"interacts"| SGMS2
    GENES["GENES"] -->|"contributes to"| SGMS2
    AND["AND"] -->|"expressed in"| SGMS2
    APOPTOSIS["APOPTOSIS"] -->|"contributes to"| SGMS2

Outgoing (75)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Ischemia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
neurodegeneration	associated_with	disease	0.61
SGMS1	interacts_with	gene	0.61
neurodegeneration	implicated_in	disease	0.60
sphingomyelin	involved_in	pathway	0.60
rat brain	expressed_in	brain_region	0.60
ceramide metabolism	regulates	pathway	0.60
drug transporters	regulates	protein	0.60
cognitive impairment	protects_against	disease	0.60
membrane raft	involved_in	pathway	0.60
ceramide phosphoethanolamine	involved_in	pathway	0.60
Japanese encephalitis virus infection	involved_in	disease	0.60
SGMS1	expressed_in	gene	0.60
CERS6	activates	gene	0.60
ASAH1	activates	gene	0.60
CERS2	activates	gene	0.60
SGMS1	inhibits	gene	0.60
ASAH1	contributes_to	gene	0.60
SGMS1	contributes_to	gene	0.60
apoptosis	involved_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
APOPTOSIS	contributes_to	gene	0.60
Apoptosis	contributes_to	pathway	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Neuron	expressed_in	cell_type	0.60
Amyloid	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
Sphingolipid	contributes_to	pathway	0.60
Aβ	activates	protein	0.60
Ras	expressed_in	protein	0.60
Fus	expressed_in	protein	0.60
oligodendrocytes	associated_with	cell_type	0.60
oligodendrocytes	inhibits	cell_type	0.60
hippocampus	expressed_in	brain_region	0.60
oligodendrocytes	regulates	cell_type	0.60
lipid metabolism	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
ALZHEIMER	inhibits	disease	0.60

Incoming (41)

Source	Relation	Type	Str
h-fdb07848	targets_gene	hypothesis	0.90
h-fdb07848	targets	hypothesis	0.80
SGMS1	regulates	gene	0.70
SGMS1	interacts_with	gene	0.61
SGMS1	co_mentioned_with	gene	0.60
SGMS1	expressed_in	gene	0.60
ASAH1	activates	gene	0.60
CERS6	activates	gene	0.60
SGMS1	inhibits	gene	0.60
CERS2	activates	gene	0.60
ASAH1	contributes_to	gene	0.60
SGMS1	contributes_to	gene	0.60
SGMS1	associated_with	gene	0.60
ASAH1	regulates	gene	0.60
GENES	contributes_to	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
GENES	expressed_in	gene	0.60
AND	contributes_to	gene	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ABCA1	debate_co_mention	gene	0.45
BACE1	debate_co_mention	gene	0.45
CYP46A1	debate_co_mention	gene	0.45
FLOT1	co_discussed	gene	0.40
SREBF2	co_discussed	gene	0.40
CYP46A1	co_discussed	gene	0.40
ST8SIA1	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
BACE1	co_discussed	gene	0.40
ST3GAL2	co_discussed	gene	0.40
SGMS1	co_discussed	gene	0.40
ABCA1	co_discussed	gene	0.40
SMPD1	co_discussed	gene	0.40
SGMS1	co_mentioned	gene	0.40
apoptosis	co_mentioned	pathway	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SGMS2

Understanding Entity Pages

Wiki Pages (19)

Sphingolipid Metabolism in Neurodegeneration

Sphingolipid Signaling Pathway in Neurodegeneration

ANG — Angiogenin

ANG Protein

Parkin Activators for Parkinson's Disease

PINK1 Activators for Parkinson's Disease

Sphingolipid Metabolism Dysregulation in 4R-Tauopathies

Sphingolipid Metabolism in Neurodegeneration

Companies

SYNA — Synapsin I

ampk-activators

PINK1-Parkin Mitophagy Activators

nrf2-activators-parkinsons-disease

NRF2 Activators in Neurodegenerative Disease

Ceramide Signaling Pathway

Ephrin Signaling Modulation Therapy

PINK1/Parkin Activators

Betz Cells (Primary Motor Cortex)