protein 1,333 words KG: WIPI2 2026-03-28
kind:proteinsection:proteinsstate:publishedtopic:alzheimerstopic:parkinsons
Contents

WIPI2 Protein

🔬 Protein Info
Gene SymbolWIPI2
AliasesPage for WIPI2, WD repeat domain, phosphoinositide-interacting protein 2
Chromosome7q36.3
Protein FamilyPROPPIN family (beta-propeller, PI3P binding)
Functionencodes a 445-amino acid protein with a molecular mass of approximately 46 kDa.
Subcellular Localizations, with WIPI2b showing predominant association with the Golgi apparatus and WIPI2a being more evenly distributed in the
Molecular Weight46 kDa
Amino Acids466 aa
Exons16
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt ID[Q9Y5P8](https://www.uniprot.org/uniprot/Q9Y5P8)
Ensembl IDENSG00000157911
GeneCardsWIPI2
Human Protein AtlasWIPI2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Carcinoma, Dementia
Known Drugs/Compoundsrapamycin
InteractionsDDB1, PI3K, LC3, UBIQUITIN, ATG16L1, ATG5
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Positioning Dynamics Modulation
Score: 0.43

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

WIPI2 associated_with BECN1
WIPI2 associated_with HDAC6
WIPI2 associated_with CREBBP
WIPI2 associated_with NBR1
WIPI2 associated_with GAPDH
WIPI2 associated_with HSP70
WIPI2 associated_with NDP52
WIPI2 associated_with VAMP8
WIPI2 associated_with EP300
WIPI2 associated_with MTOR