gene 939 words KG: CLEC7A
Contents

CLEC7A Gene

🧬 Gene Info
Gene SymbolCLEC7A
Protein TypeReceptor
FunctionCLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM.
PathwaysAmyloid, unfolded protein response, lipid metabolism
Ensembl IDENSG00000172243
GeneCardsCLEC7A
Human Protein AtlasCLEC7A
NFATgene transcription for immune activation
CARD9/BCL10/MALT1inflammasome-independent cytokine production
Associated Diseasesischemic stroke, Parkinson's disease
InteractionsAKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE
KG Connections49 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
TREM2-Dependent Microglial Senescence Transition
Score: 0.90
CYP46A1 Overexpression Gene Therapy
Score: 0.86
CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S
Score: 0.81
TREM2-mediated microglial tau clearance enhancement
Score: 0.80

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (9)

Microglia
cell · KG edge: activates
Neurodegeneration
disease · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Microglia in Neurodegeneration
entity · KG edge: activates
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: activates

Knowledge Graph (12 edges)

CLEC7A regulates Gal3
CLEC7A regulates TREM2
CLEC7A activates Syk
CLEC7A regulates NOX2
CLEC7A associated_with ischemic stroke
CLEC7A regulates synapse elimination
CLEC7A regulates microglia activation
APOE activates CLEC7A
CLEC7A activates TREM2
AXL activates CLEC7A

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