gene 1,989 words KG: NOX2 2026-03-27
kind:genesection:genesstate:published
Contents

NOX2 Gene

🧬 Gene Info
Gene SymbolNOX2
Full NameNADPH Oxidase 2
FunctionDirect microbial killing: Superoxide and derivatives
Primary Expressionhippocampus
Molecular Weight65 kDa
Amino Acids570 aa
Exons23
PathwaysOxidative Stress, oxidative stress response, Endocytosis, Immune Response, Mtor
GeneCardsNOX2
Human Protein AtlasNOX2
Electron donorNADPH provides the electrons
Associated DiseasesAlzheimer, Parkinson, Traumatic Brain Injury
Known Drugs/Compoundslevodopa
InteractionsAKT, GFAP, SRC, TLR4, TNF, EXOSOMES
KG Connections182 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: inhibits
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
CX3CR1 Modulation Therapy for Neurodegeneration
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

NOX2 activates AKT
NOX2 expressed_in SOD2
NOX2 expressed_in NRF2
NOX2 expressed_in MTOR
NOX2 inhibits GFAP
NOX2 inhibits SRC
NOX2 inhibits TLR4
NOX2 inhibits TNF
NOX2 inhibits neurodegeneration
NOX2 regulates NQO1