protein 785 words KG: NOX2
Contents

NOX2/CYBB (NADPH Oxidase 2)

🔬 Protein Info
Gene SymbolNOX2
FunctionDirect microbial killing: Superoxide and derivatives
Primary Expressionhippocampus
Molecular Weight65 kDa
Amino Acids570 aa
Exons23
PathwaysOxidative Stress, oxidative stress response, Endocytosis, Immune Response, Mtor
GeneCardsNOX2
Human Protein AtlasNOX2
Associated DiseasesAlzheimer, dopaminergic toxicity, Parkinson, parkinson-disease, Traumatic Brain Injury
Known Drugs/Compoundslevodopa
InteractionsAKT, ALZHEIMER, AND, APOPTOSIS, ASTROCYTE, ASTROCYTES
KG Connections182 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (7)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (4)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (15)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target
Astrocytes
entity · KG edge: inhibits
GFAP (Redirect)
redirect · KG edge: inhibits

Knowledge Graph (12 edges)

TNF activates NOX2
ATM activates NOX2
CLEC7A regulates NOX2
PTEN activates NOX2
PI3K activates NOX2
CX3CR1 interacts_with NOX2
NOX2 activates AKT
BAX expressed_in NOX2
NOX2 expressed_in SOD2
NOX2 expressed_in NRF2

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