gene 1,707 words KG: CD9 2026-03-27
kind:genesection:genesstate:published
Contents

CD9

🧬 Gene Info
Gene SymbolCD9
AliasesCD9 molecule
Chromosome12p21.3
Functionencodes a member of the tetraspanin family of membrane proteins, which play crucial roles in cell adhesion, membrane organization, and intercellular communication through exosome formation.
Primary Expressionvarious cell types within the central nervous system:
Molecular Weight25 kDa
Amino Acids228 aa
Exons8
PathwaysAkt, Epigenetic, Mtor, Pi3K, unfolded protein response
Ensembl IDENSG00000010278
GeneCardsCD9
Human Protein AtlasCD9
Intracellular N- and C-terminiboth are short and located in the cytoplasm
Facilitated signal transductionby bringing together signaling components
Membrane fusion eventsparticularly relevant for exosome release and cell-cell fusion
Associated DiseasesAging, Als, Alzheimer, Inflammation, Ms, Neurodegeneration
InteractionsGAIN, TREM2, AKT1, MTOR, AKT, CD81
KG Connections133 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.43

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

Generation and characterization of TIGER mice with inducible
validation · proposed · Score: 0.90
Characterization of astrocyte-derived EVs and microglia upta
exploratory · proposed · Score: 0.85
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
CD81
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CD9 activates GAIN
CD9 activates TREM2
CD9 expressed_in PMP22
CD9 associated_with GSK3B
CD9 activates AKT1
CD9 activates MTOR
CD9 activates AKT
CD9 interacts_with CD81
CD9 interacts_with CD63
CD9 phosphorylates CDK5