gene 2,588 words KG: E2F7 2026-03-26
kind:genesection:genesstate:published
Contents

E2F7 Gene

🧬 Gene Info
Gene SymbolE2F7
AliasesE2F transcription factor 7
Chromosome12q21.2
Protein TypeTranscription Factor
Functionencodes an atypical E2F transcription factor that functions primarily as a transcriptional repressor.
Molecular Weight90 kDa
Amino Acids816 aa
PathwaysCell Cycle
GeneCardsE2F7
Human Protein AtlasE2F7
E2F8Heterodimerization
RB proteinsIndirect association
HDACsRecruitment
PCBPDirect binding
p53Cross-talk
Associated Diseasesneurodegeneration
InteractionsE2F8, E2F1, E2F2, E2F3, RB1, GENES
KG Connections41 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

E2F regulation of endocycles in hepatocytes
validation · proposed · Score: 0.85
E2F coordination of G2/M transcriptional program
exploratory · proposed · Score: 0.75
E2F regulation of endocycles in trophoblast giant cells
validation · proposed · Score: 0.85

See Also (7)

Packard Center for ALS Research
institution · KG edge: inhibits
E2F8 Gene
gene · KG edge: activates
E2F3 Gene
gene · KG edge: activates
E2F Transcription Factor 2
gene · KG edge: activates
E2F1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

E2F7 activates E2F8
E2F7 activates E2F1
E2F7 activates E2F2
E2F7 activates E2F3
E2F7 interacts_with RB1
E2F7 expressed_in UBIQUITIN
E2F7 activates Nk Cell
E2F7 inhibits endocycle
E2F7 downregulates genome ploidy
E2F7 activates RB1