gene 1,816 words KG: E2F8 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

E2F8 Gene

🧬 Gene Info
Gene SymbolE2F8
Full NameE2F Transcription Factor 8
Chromosome11p15.4
Protein FamilyE2F transcription factor family
Protein TypeTranscription Factor
Functionis a member of the E2F transcription factor family that plays critical roles in regulating cell cycle progression, DNA replication, and cellular proliferation.
Molecular Weight73 kDa
Amino Acids659 aa
PathwaysCell Cycle
UniProt IDQ0VXJ8
NCBI Gene ID79733
Ensembl IDENSG00000156221
OMIM614836
GeneCardsE2F8
Human Protein AtlasE2F8
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsE2F1, E2F2, E2F3, E2F7, AND
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
PARP1 Inhibition Therapy
Score: 0.58
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

E2F regulation of endocycles in trophoblast giant cells
validation · proposed · Score: 0.85
E2F coordination of G2/M transcriptional program
exploratory · proposed · Score: 0.75
E2F regulation of endocycles in hepatocytes
validation · proposed · Score: 0.85

See Also (7)

Packard Center for ALS Research
institution · KG edge: regulates
E2F7 Gene
gene · KG edge: activates
E2F3 Gene
gene · KG edge: activates
E2F Transcription Factor 2
gene · KG edge: activates
E2F1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

E2F8 activates E2F1
E2F8 activates E2F2
E2F8 activates E2F3
E2F8 activates E2F7
E2F8 inhibits endocycle
E2F8 downregulates genome ploidy
E2F8 activates Ms
E2F8 regulates Als
E2F8 regulates DNA
E2F8 regulates Cell Cycle