E2F8

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

E2F8 is an atypical E2F transcription factor that functions as a transcriptional repressor in cell cycle regulation, DNA replication, and has emerging roles in neuronal survival and neurodegenerative diseases.

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graph TD
    E2F8["<b>E2F8</b>"]
    Ms{"Ms"}
    E2F8 -->|"activates"| Ms
    Als{"Als"}
    E2F8 -->|"regulates"| Als
    ALS{"ALS"}
    E2F8 -->|"regulates"| ALS
    E2F1["E2F1"]
    E2F8 -->|"activates"| E2F1
    E2F2["E2F2"]
    E2F8 -->|"activates"| E2F2
    E2F3["E2F3"]
    E2F8 -->|"activates"| E2F3
    E2F7["E2F7"]
    E2F8 -->|"activates"| E2F7
    DNA["DNA"]
    E2F8 -->|"regulates"| DNA
    Cell_Cycle(["Cell Cycle"])
    E2F8 -->|"regulates"| Cell_Cycle
    T_Cell["T Cell"]
    E2F8 -->|"expressed in"| T_Cell
    neurodegeneration["neurodegeneration"]
    E2F8 -->|"implicated in"| neurodegeneration
    E2F7 -->|"activates"| E2F8
    E2F1 -->|"activates"| E2F8
    E2F2 -->|"activates"| E2F8
    E2F3 -->|"activates"| E2F8
    DNA -->|"regulates"| E2F8
    AND["AND"]
    AND -->|"activates"| E2F8
    style E2F8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0