Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about E2F7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
E2F transcription factor 7 - atypical E2F functioning as transcriptional repressor
| Gene Symbol | E2F7 |
| Aliases | E2F transcription factor 7 |
| Chromosome | 12q21.2 |
| Protein Type | Transcription Factor |
| Function | encodes an atypical E2F transcription factor that functions primarily as a transcriptional repressor. |
| Molecular Weight | 90 kDa |
| Amino Acids | 816 aa |
| Pathways | Cell Cycle |
| GeneCards | E2F7 |
| Human Protein Atlas | E2F7 |
| E2F8 | Heterodimerization |
| RB proteins | Indirect association |
| HDACs | Recruitment |
| PCBP | Direct binding |
| p53 | Cross-talk |
| Associated Diseases | neurodegeneration |
| Interactions | E2F8, E2F1, E2F2, E2F3, RB1, GENES |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
E2F7["<b>E2F7</b>"]
Ms{"Ms"}
E2F7 -->|"activates"| Ms
Als{"Als"}
E2F7 -->|"regulates"| Als
ALS{"ALS"}
E2F7 -->|"regulates"| ALS
E2F8["E2F8"]
E2F7 -->|"activates"| E2F8
E2F1["E2F1"]
E2F7 -->|"activates"| E2F1
E2F2["E2F2"]
E2F7 -->|"activates"| E2F2
E2F3["E2F3"]
E2F7 -->|"activates"| E2F3
DNA["DNA"]
E2F7 -->|"regulates"| DNA
Cell_Cycle(["Cell Cycle"])
E2F7 -->|"regulates"| Cell_Cycle
T_Cell["T Cell"]
E2F7 -->|"expressed in"| T_Cell
neurodegeneration["neurodegeneration"]
E2F7 -->|"implicated in"| neurodegeneration
E2F8 -->|"activates"| E2F7
E2F1 -->|"activates"| E2F7
E2F2 -->|"activates"| E2F7
E2F3 -->|"activates"| E2F7
DNA -->|"regulates"| E2F7
AND["AND"]
AND -->|"activates"| E2F7
style E2F7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| endocycle | inhibits | process | 0.90 |
| genome ploidy | downregulates | phenotype | 0.85 |
| Ms | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | contributes_to | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| E2F8 | activates | gene | 0.60 |
| E2F1 | activates | gene | 0.60 |
| E2F2 | activates | gene | 0.60 |
| E2F3 | activates | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| UBIQUITIN | expressed_in | gene | 0.60 |
| Nk Cell | activates | cell_type | 0.60 |
| RB1 | activates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| AND | contributes_to | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| YAP | contributes_to | gene | 0.60 |
| HDAC | contributes_to | gene | 0.60 |
| AND | activates | gene | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| Hepatocyte | regulates | cell_type | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| Macrophage | expressed_in | cell_type | 0.60 |
| Ras | activates | protein | 0.60 |
| YAP | activates | gene | 0.60 |
| HDAC | inhibits | gene | 0.60 |
| YAP | inhibits | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||