gene 2,335 words KG: EBF3 2026-03-27
kind:genesection:genestopic:neurodevelopmenttopic:transcription-factortopic:alzheimerstopic:parkinsonsstate:published
Contents

EBF3 — Early B-cell Factor 3

🧬 Gene Info
Gene SymbolEBF3
Full NameEarly B-cell Factor 3
Primary Expressionmature neurons, where it contributes to synaptic plasticity and cognitive function[@coe2019][@ebf2020]
Molecular Weight65 kDa
PathwaysDna Methylation, Epigenetic
Ensembl IDENSG00000108001
GeneCardsEBF3
Human Protein AtlasEBF3
Direct DNA BindingBinds to specific palindromic sequences in target gene promoters and enhancers
Chromatin RemodelingRecruits chromatin-modifying enzymes to open or close chromatin
Transcriptional Activation/RepressionCan both activate and repress target genes depending on context
Protein Complex FormationForms homodimers and heterodimers with other COE proteins
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections26 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: regulates
TP53 Gene
gene · KG edge: regulates
RB1 — Retinoblastoma 1
gene · KG edge: associated_with
MYC Gene
gene · KG edge: regulates
MDM2 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

EBF3 regulates MYC
EBF3 regulates TP53
EBF3 regulates MDM2
EBF3 regulates GBM
EBF3 associated_with RB1
EBF3 regulates CDK4
EBF3 regulates P53
EBF3 regulates Glioblastoma
EBF3 regulates Als
EBF3 regulates Ms