gene 815 words KG: CDK4 2026-03-21
kind:genesection:genesstate:published
Contents

CDK4 Gene

🧬 Gene Info
Gene SymbolCDK4
Full NameCyclin-Dependent Kinase 4
AliasesCDK4, PSK-J3
Chromosome12q14.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight34 kDa
Amino Acids303 aa
Exons8
PathwaysAkt, Dna Methylation, Epigenetic, Pi3K
UniProt IDP11802
NCBI Gene ID1019
Ensembl IDENSG00000136492
GeneCardsCDK4
Human Protein AtlasCDK4
DrugApproval
Associated DiseasesALS, Cancer, Carcinoma, Melanoma, Migraine
InteractionsRB1, CDKN2A, CDKN1A, LCK, MCL1, ATF4
KG Connections414 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

See Also (15)

BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: activates
BECN1 Gene
gene · KG edge: activates
BCL2L1 Gene
gene · KG edge: therapeutic_target
BAX Gene
gene · KG edge: activates
ATM Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CDK4 associated_with CASP3
CDK4 regulates PI3K
CDK4 associated_with ESR1
CDK4 associated_with CHEK1
CDK4 associated_with MTOR
CDK4 associated_with PIK3CA
CDK4 associated_with GSK3B
CDK4 regulates AKT
CDK4 associated_with PARP1
CDK4 regulates RB1