| Gene Symbol | MDM2 |
| Full Name | MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase |
| Chromosome | 12q15 |
| Protein Type | Ligase |
| Function | MDM2 is a RING-finger E3 ubiquitin ligase with multiple functions: |
| Primary Expression | neurons and glia
- Higher expression in cortex and hippocampus
- Regulated by neuronal activity |
| Molecular Weight | 55 kDa |
| Amino Acids | 491 aa |
| Pathways | NF-κB |
| UniProt ID | Q00978 |
| NCBI Gene ID | 4193 |
| Ensembl ID | ENSG00000135679 |
| OMIM | 164785 |
| GeneCards | MDM2 |
| Human Protein Atlas | MDM2 |
| Associated Diseases | AGING, ALS, Alzheimer, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | PMIγ, Pmiγ |
| Interactions | SIRT1, GRB2, UBC, ATM, UBIQUITIN, RAF1 |
| KG Connections | 537 knowledge graph edges |
| Databases | GeneCardsHPASTRING |