gene 637 words KG: ERCC3 2026-03-24
kind:genesection:genesstate:published
Contents

ERCC3 Gene

🧬 Gene Info
Gene SymbolERCC3
Full NameERCC3
Chromosome19q13.32.
Protein TypeGene
Functionis a DNA repair gene located on chromosome 19q13.
Primary Expressionall human tissues, including: - Brain: neurons, astrocytes, microglia, oligodendroc
Molecular Weight89 kDa
Amino Acids782 aa
Exons17
PathwaysAkt, Mtor, PI3K-AKT-mTOR signaling, Pi3K
NCBI Gene IDSearch NCBI
GeneCardsERCC3
Human Protein AtlasERCC3
Associated DiseasesAls, Carcinoma, Cirrhosis
InteractionsCEBPB, PI3K, EGFR, MTOR, CYP3A4, AKT
KG Connections43 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (3)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (6)

Packard Center for ALS Research
institution · KG edge: activates
MTOR Gene
gene · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates
EGF Gene
gene · KG edge: activates
CYP3A4 — Cytochrome P450 3A4
gene · KG edge: activates

Knowledge Graph (12 edges)

ERCC3 activates CEBPB
ERCC3 activates PI3K
ERCC3 activates EGFR
ERCC3 activates MTOR
ERCC3 activates CYP3A4
ERCC3 activates AKT
ERCC3 activates PDK1
ERCC3 activates EGF
ERCC3 associated_with PSEN2
ERCC3 activates Cirrhosis