Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPSE LOSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SYNAPSE LOSS |
Knowledge base pages for this entity
graph TD
SYNAPSE_LOSS["SYNAPSE LOSS"]
SYNAPSE_LOSS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
SYNAPSE_LOSS -->|"correlates_with"| Cognitive_Decline["Cognitive Decline"]
C1Q["C1Q"] -->|"mediates"| SYNAPSE_LOSS
Microglia["Microglia"] -->|"mediates"| SYNAPSE_LOSS
Complement["Complement"] -->|"mediates"| SYNAPSE_LOSS
GADD45G["GADD45G"] -->|"causes"| SYNAPSE_LOSS
Inhibition_of_C1Q["Inhibition of C1Q"] -.protects against.-> SYNAPSE_LOSS
Inhibition_of_C3["Inhibition of C3"] -.protects against.-> SYNAPSE_LOSS
Alzheimer_s_Disease -->|"causes"| SYNAPSE_LOSS
NPTX2["NPTX2"] -.protects against.-> SYNAPSE_LOSS| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | contributes_to | disease | 0.95 |
| Cognitive Decline | associated_with | phenotype | 0.90 |
| Neuroplasticity | associated_with | process | 0.88 |
| Cognitive Decline | correlates_with | phenotype | 0.85 |
| COVID-19 Neuropathologies | biomarker_for | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | implicated_in | entity | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||