protein

GADD45A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GADD45A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections
0Hypotheses
0Analyses
33Outgoing
3Incoming

Summary

GADD45A is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Depression, Hypertension. Connected to 36 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolGADD45A
FunctionGADD45A is a small (165 aa) acidic protein that responds to various cellular stresses
Molecular Weight18.5 kDa
Amino Acids165 aa
PathwaysMAPK pathway, NF-κB
Ensembl IDENSG00000116729
GeneCardsGADD45A
Human Protein AtlasGADD45A
Associated DiseasesAls
InteractionsGADD45B, GADD45G, MET, INFLAMMATION, ACHE
KG Connections36 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

GADD45A Gene

gene · 662 words

H3F3B Gene — H3.3 Histone B

gene · 2806 words

GADD45G as Pathological Sensor: Orchestrating Reactive Gliosis in Neurodegeneration

mechanism · 2512 words

GADD45B Protein

protein · 2299 words

GADD45G — Growth Arrest And DNA Damage Inducible Gamma

gene · 1775 words

GADD45B — Growth Arrest and DNA Damage Inducible Beta

gene · 1763 words

Pathway Diagram

graph TD
    GADD45A["<b>GADD45A</b>"]
    Ms{"Ms"}
    GADD45A -->|"activates"| Ms
    Depression{"Depression"}
    GADD45A -->|"activates"| Depression
    GADD45A -->|"expressed in"| Ms
    Als{"Als"}
    GADD45A -->|"activates"| Als
    Inflammation{"Inflammation"}
    GADD45A -->|"activates"| Inflammation
    GADD45A -->|"regulates"| Ms
    Hypertension{"Hypertension"}
    GADD45A -->|"expressed in"| Hypertension
    GADD45B["GADD45B"]
    GADD45A -->|"activates"| GADD45B
    GADD45G["GADD45G"]
    GADD45A -->|"activates"| GADD45G
    MET["MET"]
    GADD45A -->|"activates"| MET
    Neurogenesis(["Neurogenesis"])
    GADD45A -->|"activates"| Neurogenesis
    GADD45A -->|"regulates"| GADD45B
    ACHE["ACHE"]
    ACHE -->|"activates"| GADD45A
    P62["P62"]
    P62 -->|"biomarker for"| GADD45A
    MMP9["MMP9"]
    MMP9 -->|"regulates"| GADD45A
    style GADD45A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

TargetRelationTypeStr
myofiber degenerationpromotesphenotype0.85
Msactivatesdisease0.65
Depressionactivatesdisease0.65
Msexpressed_indisease0.65
Alsactivatesdisease0.65

Incoming (3)

SourceRelationTypeStr
P62biomarker_forgene0.60
MMP9regulatesgene0.60
ACHEactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found