Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GADD45A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GADD45A is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Depression, Hypertension. Connected to 36 entities in the SciDEX knowledge graph.
| Gene Symbol | GADD45A |
| Function | GADD45A is a small (165 aa) acidic protein that responds to various cellular stresses |
| Molecular Weight | 18.5 kDa |
| Amino Acids | 165 aa |
| Pathways | MAPK pathway, NF-κB |
| Ensembl ID | ENSG00000116729 |
| GeneCards | GADD45A |
| Human Protein Atlas | GADD45A |
| Associated Diseases | Als |
| Interactions | GADD45B, GADD45G, MET, INFLAMMATION, ACHE |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GADD45A["<b>GADD45A</b>"]
Ms{"Ms"}
GADD45A -->|"activates"| Ms
Depression{"Depression"}
GADD45A -->|"activates"| Depression
GADD45A -->|"expressed in"| Ms
Als{"Als"}
GADD45A -->|"activates"| Als
Inflammation{"Inflammation"}
GADD45A -->|"activates"| Inflammation
GADD45A -->|"regulates"| Ms
Hypertension{"Hypertension"}
GADD45A -->|"expressed in"| Hypertension
GADD45B["GADD45B"]
GADD45A -->|"activates"| GADD45B
GADD45G["GADD45G"]
GADD45A -->|"activates"| GADD45G
MET["MET"]
GADD45A -->|"activates"| MET
Neurogenesis(["Neurogenesis"])
GADD45A -->|"activates"| Neurogenesis
GADD45A -->|"regulates"| GADD45B
ACHE["ACHE"]
ACHE -->|"activates"| GADD45A
P62["P62"]
P62 -->|"biomarker for"| GADD45A
MMP9["MMP9"]
MMP9 -->|"regulates"| GADD45A
style GADD45A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| myofiber degeneration | promotes | phenotype | 0.85 |
| Ms | activates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Hypertension | expressed_in | disease | 0.65 |
| Als | causes | disease | 0.65 |
| GADD45B | activates | gene | 0.60 |
| GADD45G | activates | gene | 0.60 |
| MET | activates | gene | 0.60 |
| GADD45B | regulates | gene | 0.60 |
| GADD45G | regulates | gene | 0.60 |
| P62 | biomarker_for | gene | 0.60 |
| MAPK14 | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| CTSD | regulates | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| HSPA8 | associated_with | gene | 0.60 |
| CEBPB | associated_with | gene | 0.60 |
| HSPA5 | associated_with | gene | 0.60 |
| DDIT3 | associated_with | gene | 0.60 |
| H3F3B | associated_with | gene | 0.60 |
| Neurogenesis | activates | pathway | 0.60 |
| Epigenetic | expressed_in | pathway | 0.60 |
| Dna Methylation | expressed_in | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| IMMUNE INFILTRATION | regulates | gene | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| ACHE | activates | gene | 0.60 |
| ACHE | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||