gene 1,797 words KG: GDAP1 2026-03-28
kind:genesection:genesstate:publishedtopic:parkinsonstopic:alzheimers
Contents

GDAP1 — Ganglioside-Induced Differentiation-Associated Protein 1

🧬 Gene Info
Gene SymbolGDAP1
Full NameGanglioside-Induced Differentiation-Associated Protein 1
Chromosome8q21.11
Protein FamilyMitochondrial fission proteins
Functionencodes a mitochondrial outer membrane protein that plays a critical role in regulating mitochondrial dynamics, particularly mitochondrial fission.
Subcellular Localizationthe mitochondrial outer membrane. The protein contains several functional domains:
Molecular Weight41 kDa
Amino Acids401 aa
Gene TypeProtein-coding
PathwaysAutophagy, Mitophagy
UniProt IDQ9UPN3
NCBI Gene ID78986
Ensembl IDENSG00000104381
OMIM607706
GeneCardsGDAP1
Human Protein AtlasGDAP1
Associated DiseasesAutosomal Recessive Ataxia, Neuropathy, Peripheral Neuropathy
InteractionsTFEB, AND, MITOPHAGY, AUTOPHAGY, BCL2, BNIP3
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Ganglioside Rebalancing Therapy
Score: 0.50
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (10)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
MAP1LC3A Gene
gene · KG edge: contributes_to
BNIP3L — BCL2 Interacting Protein 3 Like (NIX)
gene · KG edge: activates
BNIP3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GDAP1 activates TFEB
GDAP1 contributes_to LC3
GDAP1 causes Peripheral Neuropathy
GDAP1 causes Autosomal Recessive Ataxia
GDAP1 associated_with MFSD8
GDAP1 associated_with SETX
GDAP1 contributes_to AUTOPHAGY
GDAP1 regulates Als
GDAP1 associated_with Neuropathy
GDAP1 contributes_to Ms