gene 2,170 words KG: HIP1R 2026-03-25
kind:genesection:genesstate:published
Contents

HIP1R (Huntingtin Interacting Protein 1-Related)

🧬 Gene Info
Gene SymbolHIP1R
AliasesHIP1R, SLAIN2, B murine sarcoma virus CT10
Chromosome22q13.31
Protein TypeClathrin coat component, Actin-binding protein
Functionencodes a critical protein involved in clathrin-mediated endocytosis, actin cytoskeleton organization, and cellular trafficking.
Primary Expressionthe brain, particularly in neurons of the cortex, hippocampus, and cerebellum, where it performs essential roles in synaptic vesicle trafficking, rece
Molecular Weight~116 kDa
Amino Acids1031 aa
Ensembl IDENSG00000128284
GeneCardsHIP1R
Human Protein AtlasHIP1R
Gene NameHuntingtin Interacting Protein 1-Related
Protein Size1031 amino acids
StageHIP1R Function
InitiationRecruitment to plasma membrane sites
Associated DiseasesAls
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.40

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: associated_with
RYR2 - Ryanodine Receptor 2
gene · KG edge: regulates
ROBO1 Gene
gene · KG edge: associated_with
PIK3CB — Phosphatidylinositol-4,5-bisphosphate 3-kinase
gene · KG edge: regulates
NOS1 — Nitric Oxide Synthase 1
gene · KG edge: regulates

Knowledge Graph (11 edges)

HIP1R associated_with Als
HIP1R regulates Cardiac
RYR2 regulates HIP1R
SCN1A regulates HIP1R
ROBO1 associated_with HIP1R
GAD2 regulates HIP1R
PIK3CB regulates HIP1R
NOS1 regulates HIP1R
CFTR regulates HIP1R
EPHB4 associated_with HIP1R