gene 1,512 words KG: PIK3CB
Contents

PIK3CB — Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta

🧬 Gene Info
Gene SymbolPIK3CB
Full NamePhosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome22q13.33
Functionis a major signaling cascade in neurons
Amino Acids1048 aa
PathwaysPI3K, mTOR signaling
UniProt IDQ14184
NCBI Gene ID5293
Ensembl IDENSG00000077150
GeneCardsPIK3CB
Human Protein AtlasPIK3CB
Alternative NamesPI3Kβ, p110β
Brain RegionExpression Level
Cerebral CortexHigh
HippocampusHigh
Associated DiseasesAls, Ms
KG Connections73 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.40

Related Analyses (2)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
PIK3CA Gene
gene · KG edge: therapeutic_target
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: expressed_in
GNAI3 — G Protein Subunit Alpha I3
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PIK3CB expressed_in RALB
PIK3CB expressed_in GNAI3
PIK3CB expressed_in WIPI1
PIK3CB therapeutic_target PIK3R1
PIK3CB regulates NOS1
PIK3CB regulates CFTR
PIK3CB associated_with EPHB4
PIK3CB associated_with MMP2
PIK3CB regulates HIP1R
PIK3CB expressed_in TSC1