gene 917 words KG: GAD2 2026-03-24
kind:genesection:genesstate:published
Contents

Glutamate Decarboxylase 2

🧬 Gene Info
Gene SymbolGAD2
Full NameGlutamate Decarboxylase 2
Chromosome10p12.1
Protein TypeReceptor
FunctionIt plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expressionregions affected in Parkinson disease
UniProt IDQ96S44
NCBI Gene ID2572
Ensembl IDENSG00000136750
OMIM300036
GeneCardsGAD2
Human Protein AtlasGAD2
Associated DiseasesAls
InteractionsGAD1, PVALB, TRKB, DEPRESSION, Ras
KG Connections65 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (7)

Sex differences in CB1R-mediated cannabinoid analgesia in ne
validation · proposed · Score: 0.90
Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85
CB1R expression mapping in mPFC-vlPAG circuit
exploratory · proposed · Score: 0.85
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: therapeutic_target
HIP1R (Huntingtin Interacting Protein 1-Related)
gene · KG edge: regulates
Glutamate Decarboxylase 1
gene · KG edge: inhibits
EPHB4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GAD2 regulates PIK3CB
GAD2 regulates NOS1
GAD2 regulates CFTR
GAD2 associated_with EPHB4
GAD2 associated_with MMP2
GAD2 regulates HIP1R
GAD2 regulates USH1C
GAD2 therapeutic_target TP53
GAD2 therapeutic_target STAT3
GAD2 therapeutic_target MAPK8