gene 1,479 words KG: IDO1 2026-03-24
kind:genesection:genesstate:published
Contents

IDO1 — Indoleamine 2,3-Dioxygenase 1

🧬 Gene Info
Gene SymbolIDO1
Full NameIndoleamine 2,3-Dioxygenase 1
Chromosome8p11.21
Functionis a gene on chromosome 8p11.
Primary ExpressionMicroglia, astrocytes, macrophages, dendritic cells
Molecular Weight45 kDa
Amino Acids403 aa
Exons10
PathwaysGlycolysis, blood-brain barrier, ferroptosis, oxidative stress response, synaptic plasticity
UniProt IDP14902
NCBI Gene ID3620
Ensembl IDENSG00000131203
OMIM147435
GeneCardsIDO1
Human Protein AtlasIDO1
Associated DiseasesCancer, Infection, neuroinflammation
InteractionsGBA, YY1, IRF1, AHR, Rb, ENDOSOMES
KG Connections91 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.45
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: inhibits
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
CCL5 — C-C Motif Chemokine Ligand 5
gene · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

IDO1 catalyzes tryptophan
IDO1 produces kynurenine
IDO1 expressed_in SLC7A11
IDO1 activates GBA
IDO1 activates YY1
IDO1 activates IRF1
IDO1 inhibits SLC7A11
IDO1 activates AHR
IDO1 associated_with cancer
IDO1 inhibits ferroptosis