therapeutic 1,230 words KG: kynurenine 2026-03-26
kind:therapeuticsection:therapeuticsstate:publishedtarget:ADtarget:PDtarget:CBStarget:PSPtarget:ALStarget:FTDtarget:HD
Contents

Kynurenine Pathway Modulators for Neurodegeneration

💊 Therapeutic Info
NameKynurenine Pathway Modulators for Neurodegeneration
SummaryTherapeutic strategies targeting the kynurenine pathway including IDO/TDO inhibitors, kynurenic acid augmentation, and quinolinic acid reduction for AD, PD, CBS, PSP, ALS, FTD, HD
Key Genes/Proteinskynurenine aminotransferases, IDO1, SLC7A11
Related Diseasesferroptosis, cell_survival
Related PathwaysNAD_metabolism
Linked Hypotheses1 hypotheses

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (6 edges)

kynurenine interacts_with SLC7A11
kynurenine inhibits ferroptosis
kynurenine activates cell_survival
kynurenine participates_in NAD_metabolism
IDO1 produces kynurenine
kynurenine aminotransferases regulates kynurenine