gene 3,130 words KG: IL32
Contents

IL32

🧬 Gene Info
Gene SymbolIL32
Chromosome16p13.3
Functionis a pro-inflammatory cytokine originally identified based on its elevated expression in activated natural killer (NK) cells and T cells [1/https://pubmed.
Primary Expressionvarious cell types including T cells, NK cells, monocytes, epithelial cells, and endothelial cells
PathwaysApoptosis, Necroptosis
Ensembl IDENSG00000127124
GeneCardsIL32
Human Protein AtlasIL32
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, BAX, CCL2, CXCL10, CXCL11, CXCL9
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (5)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
necroptosis
general · KG edge: activates
TNF (Redirect)
redirect · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

BAX activates IL32
IL32 activates TNF
IL32 activates DAPK1
IL32 activates RIPK3
IL32 activates CXCL10
IL32 activates Apoptosis
IL32 activates Necroptosis
IL32 activates APOPTOSIS
IL32 activates INFLAMMATION
IL32 activates CCL2

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