gene 3,130 words KG: IL32
Contents

IL32

🧬 Gene Info
Gene SymbolIL32
Chromosome16p13.3
Functionis a pro-inflammatory cytokine originally identified based on its elevated expression in activated natural killer (NK) cells and T cells [1/https://pubmed.
Primary Expressionvarious cell types including T cells, NK cells, monocytes, epithelial cells, and endothelial cells
PathwaysApoptosis, Necroptosis
Ensembl IDENSG00000127124
GeneCardsIL32
Human Protein AtlasIL32
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, BAX, CCL2, CXCL10, CXCL11, CXCL9
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.83
TREM2-mediated microglial tau clearance enhancement
Score: 0.80
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
necroptosis
general · KG edge: activates
TNF (Redirect)
redirect · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

BAX activates IL32
IL32 activates TNF
IL32 activates DAPK1
IL32 activates RIPK3
IL32 activates CXCL10
IL32 activates APOPTOSIS
IL32 activates INFLAMMATION
IL32 activates CCL2
IL32 activates GENES
IL32 activates CXCL11

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