concept

CXCL11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

1Analyses

41Outgoing

33Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CXCL11
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, BAX, CCL2, CD8
Related Diseases	Alzheimer, Alzheimer's disease, Alzheimer'S Disease
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    CXCL11["CXCL11"]
    CXCL11 -->|"binds"| CXCR3["CXCR3"]
    CXCL11 -->|"involved_in"| Th1_Type_Response["Th1-Type Response"]
    CXCL11 -->|"involved_in"| Neuroinflammation["Neuroinflammation"]
    CXCL11 -->|"correlates_with"| T_Cell_Infiltration["T Cell Infiltration"]
    CXCL11 -->|"expressed in"| Alzheimer["Alzheimer"]
    CXCL11 -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    CXCL11 -->|"activates"| Inflammation["Inflammation"]
    CXCL11 -->|"activates"| Psoriasis["Psoriasis"]
    IFNG["IFNG"] -->|"upregulates"| CXCL11
    IFN_GAMMA["IFN_GAMMA"] -->|"activates"| CXCL11
    CXCR3 -->|"expressed in"| CXCL11
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| CXCL11
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| CXCL11
    BAX["BAX"] -->|"activates"| CXCL11
    IL32["IL32"] -->|"activates"| CXCL11
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CXCL11
    TNF["TNF"] -->|"activates"| CXCL11
    DAPK1["DAPK1"] -->|"activates"| CXCL11

Outgoing (41)

Target	Relation	Type	Str
Th1-Type Response	involved_in	process	0.85
T Cell Infiltration	correlates_with	process	0.85
Neuroinflammation	associated_with	process	0.85
CXCR3	interacts_with	protein	0.72
CXCR3 signaling	regulates	mechanism	0.70
Encephalitis	expressed_in	disease	0.65
Psoriasis	activates	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer's disease	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
CXCL9	associated_with	gene	0.60
CXCR3	associated_with	gene	0.60
multiple sclerosis	associated_with	disease	0.60
ALZHEIMER	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
Rb	associated_with	protein	0.60
KRAS	activates	gene	0.60
T Cell	associated_with	cell_type	0.60
Cytokine	associated_with	protein	0.60
T cells	expressed_in	cell_type	0.60
Chemokine	associated_with	protein	0.60
Interferon	associated_with	protein	0.60
NEURODEGENERATION	associated_with	gene	0.60
IFN	associated_with	gene	0.60
CXCL10	activates	gene	0.60
CXCL9	activates	gene	0.60
IFN	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Necroptosis	activates	pathway	0.60
CXCL12	associated_with	gene	0.60
GPR109A	associated_with	gene	0.60
GPR120	associated_with	gene	0.60
CXCR3	expressed_in	gene	0.60
CXCL10	associated_with	gene	0.60
T Cell	expressed_in	cell_type	0.55
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50

Incoming (33)

Source	Relation	Type	Str
IFNG	upregulates	protein	0.90
IFN_GAMMA	activates	protein	0.64
NEUROINFLAMMATION	associated_with	gene	0.60
BAX	activates	gene	0.60
IL32	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
DAPK1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
RIPK3	activates	gene	0.60
CCL2	activates	gene	0.60
GENES	activates	gene	0.60
CXCR3	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
IFN	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CXCL9	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CD8	associated_with	gene	0.60
CMKLR1	associated_with	gene	0.60
CD8	activates	gene	0.60
CXCL10	activates	gene	0.60
CXCL10	associated_with	gene	0.60
Alzheimer'S Disease	associated_with	disease	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
disease	associated_with	disease	0.50
Neuroinflammation	associated_with	process	0.50
CXCL10	causes	gene	0.50
CXCL9	causes	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
Neurodegeneration	associated_with	disease	0.50
CXCR3	associated_with	gene	0.50
ALZHEIMER	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

neuroimmunology | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted major safety concerns about blocking CXCL10, particularly

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Related Research

Hypotheses and analyses mentioning CXCL11 in their description or question text

No additional research found