gene 619 words KG: CXCL10 2026-03-20
kind:genesection:genesstate:published
Contents

CXCL10 - C-X-C Motif Chemokine Ligand 10

🧬 Gene Info
Gene SymbolCXCL10
Full NameC-X-C Motif Chemokine Ligand 10
Chromosome4q21
FunctionCXCL10 has essential functions in immune surveillance and inflammation:
Molecular Weight~10 kDa
PathwaysAkt, Immune Response, Inflammasome, Mapk, Pi3K
NCBI Gene ID3627
GeneCardsCXCL10
Human Protein AtlasCXCL10
Protein ClassCXC Chemokine
Cell TypeExpression Level
[Astrocytes](/entities/astrocytes)High
MicrogliaHigh
NeuronsModerate
Endothelial cellsHigh
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease
Known Drugs/CompoundsLIRAGLUTIDE
InteractionsTNF, ISG15, STAT1, MMP12, C1Q, CX3CL1
SciDEX HypothesesWhite Matter Oligodendrocyte Protection via CXCL10
White Matter Vulnerability Prevention via Oligoden
White Matter Immune Checkpoint Restoration
KG Connections926 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (30)

White Matter Oligodendrocyte Protection via CXCL10 Inhibitio
Score: 0.48
White Matter Vulnerability Prevention via Oligodendrocyte Pr
Score: 0.47
White Matter Immune Checkpoint Restoration
Score: 0.42
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51

Related Analyses (12)

Systemic immune profiling and peripheral immune contribution
neurodegeneration · completed
Does CXCL10 inhibition compromise CNS immune surveillance du
neuroimmunology · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95
CXCL10 biomarker analysis for CPSP prediction
clinical · proposed · Score: 0.90

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: biomarker_for
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with

Knowledge Graph (12 edges)

CXCL10 associated_with CD8+ T cells
CXCL10 associated_with CXCR3
CXCL10 biomarker_for MMP12
CXCL10 activates PROGRANULIN
CXCL10 activates TNF
CXCL10 regulates HSPA1A
CXCL10 regulates FGF8
CXCL10 regulates TLR4
CXCL10 activates ISG15
CXCL10 activates STAT1