gene 2,021 words KG: WIPI1 2026-03-24
kind:genesection:genesstate:published
Contents

WIPI1 Gene

🧬 Gene Info
Gene SymbolWIPI1
Full NameWIPI1
AliasesWD Repeat Domain, Pyrin Interacting 1
Chromosome1p34.2
Protein TypeGene
FunctionWIPI1 localizes to the edges of the omegasome and is essential for the recruitment of downstream autophagy proteins (Proikas-Cezanne et al., 2004).
Molecular Weight49 kDa
Amino Acids449 aa
Exons10
PathwaysAutophagy, Mitophagy, autophagy pathway, ubiquitin-proteasome
NCBI Gene IDSearch NCBI
GeneCardsWIPI1
Human Protein AtlasWIPI1
Associated DiseasesALS, Diabetes, Ms
InteractionsPARKIN, NDP52, LC3, P62, UBIQUITIN, PINK1
KG Connections86 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

p62 - Sequestosome 1 (SQSTM1)
protein · KG edge: interacts_with
Optineurin
protein · KG edge: interacts_with
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
NDP52 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

WIPI1 interacts_with PARKIN
WIPI1 interacts_with NDP52
WIPI1 interacts_with LC3
WIPI1 interacts_with P62
WIPI1 interacts_with UBIQUITIN
WIPI1 interacts_with PINK1
WIPI1 interacts_with ULK1
WIPI1 interacts_with OPTINEURIN
WIPI1 interacts_with Als
WIPI1 interacts_with Mitophagy