gene 2,021 words KG: WIPI1
Contents

WIPI1 Gene

🧬 Gene Info
Gene SymbolWIPI1
AliasesWD Repeat Domain, Pyrin Interacting 1
Chromosome1p34.2
Protein TypeGene
FunctionWIPI1 localizes to the edges of the omegasome and is essential for the recruitment of downstream autophagy proteins (Proikas-Cezanne et al., 2004).
Molecular Weight49 kDa
Amino Acids449 aa
Exons10
PathwaysAutophagy, Mitophagy, autophagy pathway, ubiquitin-proteasome
GeneCardsWIPI1
Human Protein AtlasWIPI1
PhosphorylationMultiple serine/threonine phosphorylation sites regulate WIPI1 activity and localization
Associated DiseasesAls, Diabetes, Ms
InteractionsAMPK, ATG, ATG16L1, AUTOPHAGY, BECN1, ERK
KG Connections82 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.89
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
GBA (Redirect)
redirect · KG edge: therapeutic_target
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: expressed_in
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

NDP52 recruits WIPI1
PARKIN interacts_with WIPI1
LC3 interacts_with WIPI1
NDP52 interacts_with WIPI1
PINK1 interacts_with WIPI1
ULK1 interacts_with WIPI1
P62 interacts_with WIPI1
WIPI1 interacts_with PARKIN
WIPI1 interacts_with NDP52
WIPI1 interacts_with LC3

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