gene 2,535 words KG: ARNTL 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

🧬 Gene Info
Gene SymbolARNTL
Full NameAryl Hydrocarbon Receptor Nuclear Translocator Like
AliasesBMAL1, MOP9, PASD3
Chromosome11p15.3
Protein TypeTranscription Factor
FunctionCore circadian clock transcription factor
Primary ExpressionUbiquitous, highest in SCN, cortex, hippocampus
Molecular Weight68.9 kDa
Amino Acids626
PathwaysCircadian rhythm, CLOCK-BMAL1 pathway
UniProt IDO00327
NCBI Gene ID105
Ensembl IDENSG00000141510
OMIM602550
GeneCardsARNTL
Human Protein AtlasARNTL
Associated DiseasesALS, Aging, Carcinoma, Diabetes, Ferroptosis, autism spectrum disorder
InteractionsLC3, CANCER, FERROPTOSIS, AND, MITOCHONDRIAL DNA, MTDNA
KG Connections185 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (22)

Temporal Gating of Microglial Responses
Score: 0.39
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (3)

Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
ATM Gene
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with

Knowledge Graph (12 edges)

ARNTL activates ATM
ARNTL activates BMAL1
ARNTL activates CGAS
ARNTL activates FANCD2
ARNTL activates GPX4
ARNTL activates MAP1LC3B
ARNTL activates NCOA4
ARNTL activates POLG
ARNTL activates SLC7A11
ARNTL activates STING1