gene 2,535 words KG: ent-gene-4cab11f1
Contents

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

🧬 Gene Info
Gene SymbolARNTL
Full NameAryl Hydrocarbon Receptor Nuclear Translocator Like
AliasesBMAL1, MOP3
Chromosome11p15.3
Protein TypeTranscription Factor
FunctionCore circadian clock transcription factor
Primary ExpressionUbiquitous, highest in SCN, cortex, hippocampus
Molecular Weight68.9 kDa
Amino Acids626
PathwaysCircadian rhythm, CLOCK-BMAL1 pathway
UniProt IDO00327
NCBI Gene ID105
Ensembl IDENSG00000133794
OMIM602550
GeneCardsARNTL
Human Protein AtlasARNTL
Associated DiseasesAging, ALS, autism spectrum disorder, Carcinoma, Diabetes, Ferroptosis
InteractionsAGING, ALOX, AND, ATG, BMAL1, CANCER
SciDEX HypothesesMicroglial-Specific Circadian Gene Therapy
BMAL1-CLOCK regulation of miR-143/145 locks microg
KG Connections186 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.59
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
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Related Analyses (10)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (3)

Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ATM Gene
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits

Knowledge Graph (4 edges)

h-5405873559 targets ent-gene-4cab11f1
ent-gene-4cab11f1 targeted_by h-5405873559
ent-gene-4cab11f1 data_in benchmark_ot_ad_answer_key:ARNTL
benchmark_ot_ad_answer_key:ARNTL data_in ent-gene-4cab11f1

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